⚡ Peanut Allergy: A Short Story

Friday, July 30, 2021 1:16:28 PM

Peanut Allergy: A Short Story



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Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. Authors of a new study published in the New England Journal of Medicine say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy. The medication, called AR, is derived from peanut protein.

Of eligible participants ages 4 to 17, received the AR oral medication, while the remainder received a placebo drug. At the end of the trial, more than two-thirds of the group taking the active drug were able to tolerate a dose of peanut protein equivalent to about two peanut kernels. Despite this, not a single treatment for food allergy has been approved by the FDA. According to the study, oral immunotherapy for peanut allergy has been recommended against in most clinical settings because past trials have been limited by small sample sizes and differing methodologies.

Participants of the PALISADE trial were instructed to continue the standard of care for peanut allergy, which meant eliminating peanuts from their diets and carrying self-injectable epinephrine an emergency medical treatment for accidental exposure. Qualifying participants started with a one-day supervised increase in dosage from 0. When adverse reactions occurred, the study protocol allowed for adjustments to the dosing schedule. Compared to the placebo group, participants who took AR had less severe allergy symptoms. Vickery et al.

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